Browsing by Author "Ighodaro Osasenaga Macdonald"

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    A Time Course Study on Blood Chemistry and Haematological Parameters of Albino Rats Exposed To Microwaved Pellets
    (Animal Research International, 2021) Ikanone Christopher Efe Oritseweyinmi; Akinloye Oluseyi Adeboye; Ugbaja Regina Ngozi; Ighodaro Osasenaga Macdonald; Chiderah Chukwurah Chiamaka
    Different studies have implicated radiations in diverse health anomalies including genetic mutations and carcinogenesis. The present study sought to investigate any changes in vital blood chemistry indices following intake of micro wave pellet over different lengths of time using animal model (Wistar rats). Thirty-six adult male rats were randomized into three groups (n = 12). Group 1 animals (control) were fed with normal pellets; groups 2 and 3 animals were respectively fed with indirectly and directly micro waved pellets, and water ad libitum. Four animals were sacrificed weekly for three weeks from each group and blood samples were collected by cardiac puncture for biochemical analyses. Plasma levels of total protein, cholesterol, triglyceride, high density lipoprotein (HDL), low density lipoprotein (LDL), alkaline phosphatase (ALP), aspartate aminotransferase (AST), alanine aminotransferase (ALT), bilirubin and haematological indices were determined using standard procedures. Comparative analyses of the control and experimental groups showed that intake of micro waved pellets (both direct and indirect) caused significant (p<0.05) alterations in the physiological levels of total cholesterol, total triglyceride, HDL, LDL, ALP, AST, ALT, total protein, total and indirect bilirubin, by the third week. Although, these parameters did not significantly changed within the first two weeks, but significant (p<0.05) changes in haematological parameters were noticed right from the first week of micro waved pellet intake. Collectively, the outcome of this study apparently substantiates the health risk commonly associated with the intake of micro waved food and therefore discourages its consumption.
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    Biochemical Evaluation of the Heart and Liver Homogenate of Female Albino Rat Exposed to Microwave Pellets.
    (Crawford Journal of Natural and Applied Sciences, 2019) Ikanone Christopher Efe Oritseweyinmi; Amaihian L.E.; Ighodaro Osasenaga Macdonald; Rahman S.A.
    Intake of microwave food is increasingly becoming a cause for concern due to health risk often associated with exposure to radiations. Different studies have implicated radiation in diverse health abnormalities including genetic mutations and carcinogenesis. The aim of the study is to evaluate some biochemical parameters and histopathological studies of the heart and liver homogenate of female albino rat exposed to microwave pellets. Twenty four (N=24) female albino rats were used for the study and were randomly divided into 4 groups of six animals per group namely control, ceramic, plastic and aluminum groups. Control group were fed normal rat pellet, while the other groups were fed rat pellets exposed to microwave ceramic, plastic and aluminium plates respectively and water ad libitum for four weeks. Creatine kinase (CK) and lactate dehydrogenase (LDH) activities were evaluated in the heart homogenate while alanine aminitransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) activities were evaluated in the liver. Total protein was also determined in both organs. Histopathological assay of the organs were also examined using standard technique. Results of the analysis showed that there were significant differences (P<0.05) in the biochemical parameters evaluated compared with the control group and photomicrographs of the tissues reveal that the structural integrity of the heart and liver cells were altered and this might compromise their functions due to continuous exposure to microwave diet. The study proves that microwave radiation may cause injuries in the organs in respective of the utensils used.