Browsing by Author "Ogunlana Oluseyi Ebenezer"

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    Investigating prospects of Phyllanthus muellerianus as ecofriendly/ sustainable material for reducing concrete steelreinforcement corrosion in industrial/microbial environment
    (Energy Procedia, 2015) Ogunlana Oluseyi Ebenezer; Okeniyi Joshua Olusegun; Omotosho Olugbenga Adeshola; Ogunlana Olubanke Olujoke; Okeniyi Elizabeth Toyin; Owoeye Taiwo Felicia; Ogbiye Adebanji Samuel
    Characterization and experimental modelling were employed for investigating prospects of Phyllanthus muellerianus as eco-friendly/sustainable material for reducing concrete steel-reinforcement corrosion in industrial/microbial environment. Atomic Absorption Spectroscopy/Fourier Transform Infra Red Spectroscopy of the inorganic and organic constituent of the leaf, as well as total-corrosion effects of the leaf-extract admixture in steel-reinforced concrete were requisitely analyzed and interpreted. Results showed that Phyllanthus muellerianus is constituted of non-toxic level of inorganic/heavy metals, useful phytochemical constituents and essential heteroatoms that makes it potent with excellent reduction effects on the total-corrosion model of steel-reinforcement in concrete immersed in the industrial/microbial simulating-environment studied.
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    Potential Anti-Cancer Flavonoids Isolated From Caesalpinia bonduc Young Twigs and Leaves: Molecular Docking and In Silico Studies
    (Bioinformatics and Biology Insights, 2019) Ogunlana Oluseyi Ebenezer; Ogunlana Olubanke Olujoke; Iheagwam Franklyn Nonso; Isewon Itunuoluwa; Oyelade Jelili
    Tyrosine kinase (TK), vascular endothelial growth factor (VEGF), and matrix metalloproteinases (MMP) are important cancer therapeutic target proteins. Based on reported anti-cancer and cytotoxic activities of Caesalpinia bonduc, this study isolated phytochemicals from young twigs and leaves of C bonduc and identified the interaction between them and cancer target proteins (TK, VEGF, and MMP) in silico. AutoDock Vina, iGEMDOCK, and analysis of pharmacokinetic and pharmacodynamic properties of the isolated bioactives as therapeutic molecules were performed. Seven phytochemicals (7-hydroxy-4′-methoxy-3,11 dehydrohomoisoflavanone, 4,4′-dihydroxy-2’-methoxychalcone, 7,4′-dihydroxy-3,11-dehydrohomoisoflavanone, luteolin, quercetin-3-methyl, kaempferol-3-O-β d-xylopyranoside and kaempferol- 3-O-α-l-rhamnopyranosyl-(1 → 2)-β-D-xylopyranoside) were isolated. Molecular docking analysis showed that the phytochemicals displayed strong interactions with the proteins compared with their respective drug inhibitors. Pharmacokinetic and pharmacodynamic properties of the compounds were promising suggesting that they can be developed as putative lead compounds for developing new anti-cancer drugs.