Browsing by Author "Omadime M."

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    Antimicrobial Activity of Essential Oil and Extracts of Gongronema latifolium Decne on Bacterial Isolates from Blood Stream of HIV Infected Patients
    (Journal of Pharmacology and Toxicology, 2011) Agbaje-Daniels Folashade; Adeleye Isaac Adeyemi; Omadime M.
    The essential oil as well as aqueous and ethanolic extracts of Gongronema latifolium leaves was evaluated for antimicrobial activity against bacteria isolated from blood streams of HIV patients in Lagos. Using agar diffusion method, the essential oil and the extracts showed moderate inhibitory activity against all the Stphylococcus sp., Escherichia coli, Shigella sp., Salmonella sp., Klebsiella pneumonia, Pseudomonas aeruginosa, Onchrobactrum anthropi and Candida albicans. The zones of inhibition values recorded were comparable to control antibiotic ampicillin but less than that of Ciprofloxacin and Chloramphenicol. The MIC for essential oil ranged between 5-40 μg mL-1, while MBC also ranged between 5-40 μg mL-1, the MIC and MBC for ethanol extract ranged between 3.125-12.5 mg mL-1 and 3.125-25.0 mg mL-1, while aqueous extract MIC range between 6.25-25.0 mg mL-1 and MBC also ranged between 6.25-25.0 mg mL-1, respectively. Extracts of Gongronema latifolium may be useful in ethnomedicine and in the treatment of blood stream infections in HIV patients. Essential oil from Gongronema latifolium leaves (Endl.) Decne was obtained by hydrodistillation and analyzed using Gas Chromatography/Mass Spectrophotometry (GC-MS). The oil was dominated by linear aliphatic compounds (27.06%),unsaturated fatty acids which was characterized by high percentage of Phthalic acid (18.61%), oleic acids (5.2%), arachidic acid (2.34%) and fumaric acid (2.22%). Monoterpenes including camphor, β-Cymene and phytol.
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    Characterization of Volatile Components of Epa-Ijebu: A Native Wonder Cure Recipe
    (Journal of Pharmacology and Toxicology, 2011) Agbaje-Daniels Folashade; Adeleye Isaac Adeyemi; Omadime M.
    Essential oils and volatile compound from Epa-Ijebu, a native cure-all concoction was extracted by hydrodistillation and analyzed using Gas Chromatography/ Mass Spectrometry (GC-MS) in an attempt to determine the major constituents that could be responsible for the acclaimed curative ability of this concoction over diverse illnesses. Twelve major organic compounds were identified of which Fatty acids were most prevalent (35.52%). This was followed by normal alkanes such as nonadecene, hexadecane, heptadecane, octadecane and heneicosane (constituting 26.5%),2-p-nitrophenyl-oxadiazol-1,3,4-one-5 (18.18%), Quinoline (5.96%), Benzothiazole (4.87%) , Alcohol (2.48%) and other compounds in traces. The prevalence of fatty acid extracts as well as quinoline, benzothiazole and alchohol may be responsible for the anti-bacterial and antifungal as well as other curative ability of this local concoction.