Browsing by Author "Ugbaja Regina Ngozi"

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    A Time Course Study on Blood Chemistry and Haematological Parameters of Albino Rats Exposed To Microwaved Pellets
    (Animal Research International, 2021) Ikanone Christopher Efe Oritseweyinmi; Akinloye Oluseyi Adeboye; Ugbaja Regina Ngozi; Ighodaro Osasenaga Macdonald; Chiderah Chukwurah Chiamaka
    Different studies have implicated radiations in diverse health anomalies including genetic mutations and carcinogenesis. The present study sought to investigate any changes in vital blood chemistry indices following intake of micro wave pellet over different lengths of time using animal model (Wistar rats). Thirty-six adult male rats were randomized into three groups (n = 12). Group 1 animals (control) were fed with normal pellets; groups 2 and 3 animals were respectively fed with indirectly and directly micro waved pellets, and water ad libitum. Four animals were sacrificed weekly for three weeks from each group and blood samples were collected by cardiac puncture for biochemical analyses. Plasma levels of total protein, cholesterol, triglyceride, high density lipoprotein (HDL), low density lipoprotein (LDL), alkaline phosphatase (ALP), aspartate aminotransferase (AST), alanine aminotransferase (ALT), bilirubin and haematological indices were determined using standard procedures. Comparative analyses of the control and experimental groups showed that intake of micro waved pellets (both direct and indirect) caused significant (p<0.05) alterations in the physiological levels of total cholesterol, total triglyceride, HDL, LDL, ALP, AST, ALT, total protein, total and indirect bilirubin, by the third week. Although, these parameters did not significantly changed within the first two weeks, but significant (p<0.05) changes in haematological parameters were noticed right from the first week of micro waved pellet intake. Collectively, the outcome of this study apparently substantiates the health risk commonly associated with the intake of micro waved food and therefore discourages its consumption.
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    Effect of Sub-Acute Exposure to Bonny Light Crude Oil On Plasma Biochemistry and Liver Histopathology of Albino Rat
    (Animal Research International, 2017) Ikanone Christopher Efe Oritseweyinmi; Akinloye Oluseyi Adeboye; Ugbaja Regina Ngozi; Omotainse Samuel Olatunbosun; Ajayi Olusola Lawrence; Shopein Tolumide Michael
    The study investigated the consequences of the effect of sub-acute exposure to Nigerian Bonny Light Crude Oil (BLCO) crude oil on the blood chemistry and integrity of the liver of male albino rats. A total of 20 male wistar rats were used for the study. Exposure to crude oil was achieved by oral administration of increasing doses (0.25, 0.50, 0.75 and 1.0 ml of BLCO/g body weight) to the rats every day for two weeks. The initial and final body weights were recorded. The toxic effects on the liver were accessed using commercial kits and histopathological studies were carried out using standard histopathological technique. The results revealed that liver cells were damaged due to the crude oil administered. There was significant increase (p<0.05) in alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) activities and total and direct bilirubin concentrations, and a significant decrease (p<0.05) in the total protein concentration as compared with the control group. Histopathological examinations indicated that crude oil caused severe pathological changes, it also revealed mild to severe disruption of the normal architectural structure of the liver accompanied by the death of many liver cells and the presence of pocket of blood within the liver parenchyma and cholangitis in the group treated with the highest dose (1.00 ml of BLCO /g body weight). The results therefore indicate that the sub-acute administration of the crude oil brought about impaired function of the liver which could lead to liver disease at very low doses and are such the use of the crude oil as a therapy to poisons, convulsion and other gastrointestinal disorders should be discouraged.